1) Carbonylation, 2) Amination, 3)C-S Coupling, 4) Sonogashira Coupling 5) Suzuki Coupling,
6) Halogen-CN-Exchange, 7) Malodinitrile Coupling, 8) Heck Coupling

The ability to create CX bonds, mainly C-C and C-N bonds, by homogeneous catalysis represents a powerful tool in organic chemistry and is omnipresent in todays APIs. We have the tools and experience to develop scalable and robust CX-coupling process. From screening of new catalytic systems using a modern HTS infrastructure to focussed DOE (design of experiments, Stavex) and subsequnert optimization to the final proof of concept scale-up, we offer you’re a fast and costs effective solution.

Routinely we optimize reactions like:

• Buchwald-Hartwig Amination (incl. direct Amination in the presence of Ammonia)
• Cyanation,
• Carbonylation, Hydroformylation and reductive Hydroformylation
• Heck, Sonogashira Coupling, Suzuki-Miyaura and Vinylation
• With one of the most comprehensive set (e.g. cataCXium®, Palladacycles, Josiphos) of industrial relevant proprietary and non proprietary ligands on stock, we are ready for a fast turnaround of your project from screening to rapid scale-up as proof of concept.